Results
| PMID | 11783354 |
| Gene Name | CCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 50 |
| Population details | 50 (30 patients with endometriosis, 20 patients without endometriosis as controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Fu Chan Ke Za Zhi. 2001 Feb;36(2):89-91. Tan, X| Lang, J| Liu, D Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. OBJECTIVE: To examine the expression of monocyte chemotactic protein-1 (MCP-1) messenger ribonucleic acid (mRNA) in the endometrium of patients with and without endometriosis. METHODS: A reverse transcription-polymerase chain reaction (RT-PCR) method was utilized to examine and quantitate MCP-1 mRNA expressions and levels in the eutopic endometrium. Thirty patients with endometriosis were included as study group, and 20 patients without endometriosis selected as control group. RESULTS: 26 (87%) of 30 samples of endometrium from patients with endometriosis expressed MCP-1 mRNA, 19 of which were strong expression, while 15 (75%) of 20 samples of endometrium from patients without endometriosis express MCP-1 mRNA (P > 0.05). When endometriosis were grouped by Revised American Fertility Society (RAFS) stages, there was no obvious correlation between stage and MCP-1 mRNA expression level (P > 0.05). Semi-quantitative PCR showed the expression level of MCP-1 in endometrium of patients with endometriosis were higher than those of patients without endometriosis (0.746 +/- 0.345 Vs 0.460 +/- 0.341 respectively, P < 0.05). CONCLUSIONS: The MCP-1 mRNA is over expressed in the eutopic endometrium from patients with endometriosis, which may play some roles on the pathogenesis of endometriosis. Mesh Terms: Adult| Chemokine CCL2/*biosynthesis| Choristoma/*metabolism| Endometriosis/*metabolism| *Endometrium| Female| Humans|DA 2002/01/23 10:01 |
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